New PDF release: Antioxidants in Andrology

By Giancarlo Balercia, Loredana Gandini, Andrea Lenzi, Francesco Lombardo

ISBN-10: 3319417479

ISBN-13: 9783319417479

ISBN-10: 3319417495

ISBN-13: 9783319417493

This publication makes a speciality of using quite a few molecules with antioxidant homes within the therapy of significant male genital tract problems, particularly male infertility, erectile disorder, and accent gland an infection. The insurance additionally contains dialogue of pathophysiology, the molecular foundation of male infertility, and the reason to be used of antioxidants, with specific cognizance to coenzyme Q10 and carnitine. Oxidative rigidity happens whilst the construction of reactive oxygen species, together with unfastened radicals, exceeds the body’s traditional antioxidant defences, resulting in mobile harm. Oxidative pressure is found in approximately 1/2 all infertile males, and reactive oxygen species can produce infertility either through destructive the sperm membrane, with effects for sperm motility, and through changing the sperm DNA. there's therefore a transparent purpose for using antioxidant remedies inside andrology, and diverse in vitro and in vivo reviews have indicated that many antioxidants certainly have helpful affects. In delivering a close and up to date evaluate of the topic, this publication can be of curiosity to either practitioners and researchers in andrology, endocrinology, and urology.

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Eur J Prev Cardiol. 2016. pii: 2047487316659573. [Epub ahead of print] Review. 16. Kagan V, Serbinova E, Packer L. Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling. Biochem Biophys Res Commun. 1990;169(3): 851–7. PubMed PMID: 2114108. 17. Kamei M, Fujita T, Kanbe T, Sasaki K, Oshiba K, Otani S, Matsui-Yuasa I, Morisawa S. The distribution and content of ubiquinone in foods. Int J Vitam Nutr Res. 1986;56(1):57–63. PubMed PMID: 3710719. P. Littarru et al.

2 ±. 01, respectively). These data were also confirmed in larger series of patients [12, 33, 34]. Since CoQ10 in seminal plasma did not correlate with LDH levels, we concluded that the amounts of CoQ10 in plasma were not due to spermatozoa damage and to a consequent release of ubiquinone from the cells. We hypothesized that seminal plasma CoQ10 levels reflect an interchange between cellular and extracellular compartments, with a pathophysiological meaning similar to serum ubiquinone values [35, 36]; a relative deficiency or utilization of CoQ in sperm cell was therefore supposed to be present in varicocele condition [37].

20. Lamperti C, Naini AB, Lucchini V, Prelle A, Bresolin N, Moggio M, Sciacco M, Kaufmann P, DiMauro S. Muscle coenzyme Q10 level in statin-related myopathy. Arch Neurol. 2005; 62(11):1709–12. 21. Littarru GP, Tiano L, Belardinelli R, Watts GF. Coenzyme Q(10), endothelial function, and cardiovascular disease. Biofactors. 2011;37(5):366–73. 154. 22. Littarru GP, Langsjoen P. Coenzyme Q10 and statins: biochemical and clinical implications. Mitochondrion. 2007;7 Suppl:S168–74. 7 23. Mancini A, De Marinis L, Littarru GP, Balercia G.

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Antioxidants in Andrology by Giancarlo Balercia, Loredana Gandini, Andrea Lenzi, Francesco Lombardo


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