Get Antiandrogens in Prostate Cancer: A Key to Tailored PDF

By Louis Denis (auth.), Professor Dr. Louis Denis (eds.)

ISBN-10: 3642457452

ISBN-13: 9783642457456

ISBN-10: 3642457479

ISBN-13: 9783642457470

The creation of maximal androgen blockade as a scientific treatment via Brachi and Labrie greater than a decade in the past ended in an enormous controversy at the scientific use of antiandrogens within the therapy of prostate melanoma. 3 consensus conferences have been accordingly prepared with the aid of the yank melanoma Society, the Urological workforce of the ecu association for study and remedy of melanoma and the overseas Prostate health and wellbeing Council. the 1st result of the meta-analysis of twenty-two trials didn't positioned an finish to the debate, even though, and clinicians have been left harassed by way of conflicting stories released by means of dozens of specialists. The assembly at the back of the current quantity created a discussion board for the scientists who built the medication and expert clinicians to provide a consensus. the result's an outline of the sphere, condensed from hundreds and hundreds of guides. the knowledge has been up to date to supply special scientific symptoms for using antiandrogens together remedies and monotherapy for the person sufferer. we are hoping that this crew attempt will facilitate ongoing discussions and bring about more advantageous sufferer care in addition to elevated wisdom of the medicine which are so important to our sufferers' caliber of lifestyles and survival.

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Extra info for Antiandrogens in Prostate Cancer: A Key to Tailored Endocrine Treatment

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The only possible cause of feminisation could be androgen deficiency. There were two possibilities: either CPA inhibited the androgen biosynthesis in the fetal testes or this compound inhibited the action of androgens in one way or another directly at the target organ level. The following experiment proved the second theory to be correct (see Fig. 3). In this experiment, castrated mice were given testosterone propionate. The parameters used for androgenicity were seminal vesicle and prostate weights.

Proc Natl Acad Sci USA 1987 (84):8380-8384 27 121 Ponglikitmongkol M, Green S, Chambon P: Genomic organization of the human oestrogen receptor gene. EMBO J 1988 (7):3385-3388 122 Faber PW, Kuiper GGJM, van Rooij HCJ, van der Korput JAGM, Brinkmann AO, Trapman J: The Nterminal domain of the human androgen receptor is encoded by one, large exon. Mol Cell Endocrinol 1989 (61 ):257-262 123 Evans RM and Hollenberg SM: Zinc fingers: Gilt by association. Cell 1988 (52): 1-3 124 Green Sand Chambon P: Nuclear receptors enhance our understanding of transcription regulation.

Br J Dermatol 1973 (89):487490 42 Wendt Hand HOmmelinck R: The effect of cyproterone acetate on some endocrinological parameters. In: Hammerstein J, Lachnit-Fixson U, Neumann F, Plewig G (eds) Androgenization in Women - Acne, Seborrhoea, Androgenetic Alopecia and Hirsutism. Excerpta Medica, Amsterdam, Oxford, Princeton 1980 pp 259-265 43 Girard J, Helge H, and v. MOhlendahl KE: Treatment of idiopathic precocious puberty with cyproterone acetate. Horm Res (Basel) 1978 (9):301-312 44 Poyet P and Labrie F: Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and megestrol acetate.

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Antiandrogens in Prostate Cancer: A Key to Tailored Endocrine Treatment by Louis Denis (auth.), Professor Dr. Louis Denis (eds.)

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