By Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)
Basic learn on osteoarthritis has been performed normally from the his tological and biochemical facets of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical pressure has been proven to be the crucial consider the initiation of osteoarthritis. even supposing the precise approach during which mechanical pressure ends up in the entire destruction of cartilage tissue is still doubtful, a number of new study equipment have enabled us to realize a deeper knowing of the method of degeneration. In October 1997, we prepared a world symposium titled "Ad vances in Osteoarthritis" in Kobe, with the most subject matters being up-to-date re seek, prognosis, and therapy of osteoarthritis. The complaints of the symposium are provided right here in 5 sections: (1) Mechanical tension and reactions of chondrocytes, equivalent to intracellular ion adjustments, adjustments within the cytoskeleton, intracellular messenger structures, unlock of fuel mediators, and adjustments in electromechanical homes of cartilage; (2) useful analysis of osteoarthritis by way of MR imaging, and utilizing calpain and collagenase III as new cartilage markers; (3) remedy with a promising basic washout process and IL-1RA and MMP antagonists; (4) Cartilage fix through new grafting tech niques; and (5) difficulties following overall joint substitute. We basically wish that the complex wisdom supplied during this quantity of lawsuits should be priceless to our readers.
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Fisher (biglycan), and Dr. T. Krusius (decorin and versican) Continuous 30-MPa hydrostatic pressure caused a retarded mobility of aggrecans in agarose gel electrophoresis . This slowing was probably caused by the high magnitude of the pressure, and not by the static mode of the loading, because a 5-MPa continuous pressure did not have a similar effect. A change into a higher molecular weight aggrecan was in line with the finding that in Sephacryl S-lOOO gel chromatography the peak of the monomeric large PGs shifted into a smaller Kav value.
The loading creates hydrostatic pressure pulses that immediately spread into the underlying cartilage around the contact site. The hydrostatic pressure resulting from mechanical loading induces a flow of fluid through the matrix and creates streaming potentials and currents. Utilizing a pressure chamber, the effects of hydrostatic pressure can be investigated independently from other factors associated with mechanical loading. Increased hydrostatic pressure influences various cell types such as bonederived cells [32,33] and osteoblastoma cells .
Parkkinen J, Lammi M, Inkinen R, et al (1995) Influence of short-term hydrostatic pressure on organization of stress fibers in cultured chondrocytes. J Orthop Res 13:495-502 33. Tang D, Tarrien M, Dobrzynski P, et al (1995) Melanoma cell spreading on fibronectin induced by 12(S)-HETE involves both protein kinase C- and protein tyrosine kinase-dependent focal adhesion formation and tyrosine phosphorylation of focal adhesion kinase (pp125FAK). J Cell PhysioI165:291-306 34. Barry S, Critchley D (1994) The Rho A-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-O to focal adhesion.
Advances in Osteoarthritis by Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)